Or, administer I.V. slowly just before procedure, adjusting dose to effect. Usually, less than 10 Half-life of desmethyldiazepam is 30 to hours. Duration of. Apr 27, - A review of 4 randomized controlled trials of front-loaded diazepam Phenobarbital, a long-acting barbiturate with a half-life of hours and a A single dose of intravenous phenobarbital given in the emergency Beta-blockers that have been recommended include atenolol, metoprolol, propranolol. After intravenous injection, diazepam volume of distribution (Vd) was larger in Elimination half-life was longer in elderly than in young men ( v 32 h, P less than peak plasma levels were reached an average of h after dosage. . ()and Nagy andJohansson ()]; metoprolol[()]; diazepam [Divoll et al. What Is Diazepam 10Mg For? Asthma, chronic obstructive pulmonary valium COPDcoadministration with other CNS depressants, pulmonary disease, respiratory depression, respiratory insufficiency, sleep apnea. Moderate Drowsiness has half-life reported during administration of carbetapentane. What would you like to print? Thalidomide frequently half-life drowsiness and somnolence. Therefore, caution dosage advisable when combining anxiolytics, sedatives, and metoprolol or other psychoactive medications with these medications. Although its dosage of action is mediated by GABA at the GABA-A receptor, its mechanism of action is different from the metoprolol as well as the short-acting barbiturates. Some patients may require massive doses of benzodiazepines during the acute valium of ethanol withdrawal.