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Although the combination has been used safely, adverse reactions such as confusion, ataxia, somnolence, delirium, collapse, cardiac arrest, respiratory arrest, and death have occurred rarely in patients receiving clozapine concurrently or following benzodiazepine therapy. Moderate Administering diazepam with elbasvir; grazoprevir may result in elevated diazepam plasma concentrations. Amphetamines may decrease the seizure threshold and may increase the risk of seizures. Major Fluvoxamine decreases the oxidative hepatic metabolism of diazepam. In general, all forms of diazepam should be administered cautiously to patients with mild to moderate hepatic disease, cirrhosis, hepatic fibrosis, and acute or chronic hepatitis, because its elimination half-life can be prolonged, possibly resulting in toxicity. Concurrent use of topiramate and benzodiazepines associated with thrombocytopenia e. Flumazenil does not affect the pharmacokinetics of portal
benzodiazepines. Severe complications are account
commonly encountered in older people or gravely ill patients. Major Use caution if mitotane and diazepam are used concomitantly, valium
monitor for decreased patient
of diazepam and infiltrate
possible change in dosage requirements. Calcium Carbonate; Magnesium Hydroxide: In adults, intravenous administration should not exceed a rate of 50mg per minute. Moderate Diazepam is metabolized by oxidative metabolism which may be decreased by telithromycin and caution is recommended.